What have we learnt from Vioxx?
نویسندگان
چکیده
http://bmj.com/cgi/content/full/334/7585/120 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/334/7585/120/DC1 "References" Rapid responses http://bmj.com/cgi/eletter-submit/334/7585/120 You can respond to this article at: http://bmj.com/cgi/content/full/334/7585/120#responses free at: 2 rapid responses have been posted to this article, which you can access for
منابع مشابه
Publication Bias in Meta-Analysis
Publication bias is the term for what occurs whenever the research that appears in the published literature is systematically unrepresentative of the population of completed studies. Simply put, when the research that is readily available differs in its results from the results of all the research that has been done in an area, readers and reviewers of that research are in danger of drawing the...
متن کاملAn underrecognized challenge in evaluating postmarketing drug safety.
The withdrawal of the cyclooxygenase (COX)-2–specific inhibitor rofecoxib (Vioxx; Merck) has generated a high-profile debate in the medical and lay press over when a signal suggesting the potential for harm from this drug was first apparent and what steps the medical community, the US Food and Drug Administration, and the pharmaceutical sponsor took and should have taken to address this issue.1...
متن کاملWorldwide drug withdrawal puts FDA under scrutiny Merck faces 300 lawsuits Karen
Vioxx is a cyclooxygenase (COX)-2 selective, non-steroidal anti-inflammatory drug (NSAID) that was approved by the USA’s Food and Drug Administration (FDA) in May 1999 for the relief of the signs and symptoms of osteoarthritis, the management of acute pain in adults, and the treatment of menstrual symptoms. Vioxx was later also approved for the relief of signs and symptoms of rheumatoid arthrit...
متن کاملCardiac Toxicity: Issue for Drug Safety; Goal for Prediction
blockbuster COX-2 inhibitor Vioxx (rofecoxib) as a result of an increased risk of heart attack in Vioxx users underscores the prominent role that cardiac toxicity continues to play in ensuring drug safety within the pharmaceutical industry. While the precise mechanism of Vioxx-induced cardiotoxicity is unclear, cardiac liabilities have surfaced recently for a surprising number of approved drugs...
متن کاملLessons Learnt from the JPEG Case Study: Extended View on Design-Space Exploration Approaches
PROJECT : Architecture Exploration REPORT : 3 SUBJECT : Lessons Learnt from the JPEG Case Study: Extended View on DesignSpace Exploration Approaches DATE : May 13, 2002. ABSTRACT : We report on lessons we have learnt from the JPEG case study. We report on what came out of this case study. Beside this, we report on new solutions that we have found. Finally, we give pinpoints about the implementa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- BMJ
دوره 334 7585 شماره
صفحات -
تاریخ انتشار 2007